Like many other sertraline effects, sexual side effects can often fade over time as your body gets used to the medication. In women, the most common sexual side effect of sertraline and other SSRIs is a lower level of interest in sex. Some men also experience a lower general level of interest in sex after using SSRIs such as sertraline. In men, one of the most common side effects is a higher level of difficulty achieving orgasm and ejaculating. These side effects can affect both men and women.

It’s worth noting the research did find that of the SSRIs, sertraline has one of the lower likelihoods of affecting sexual function. Sexual side effects are some of the most common side effects of sertraline and other commonly used SSRI medications.Īccording to a review of certain studies, between 40 percent and 65 percent of people who take SSRIs experience some side effects related to sexual desire and performance. Sertraline and other SSRIs can cause a variety of sexual side effects, from difficulty achieving orgasm, to a decreased sex drive and erectile dysfunction. If you have persistent fatigue or drowsiness after starting sertraline that doesn’t disappear within one month, it’s best to contact your healthcare provider. It’s very common to feel a little low in energy during the first few weeks of taking sertraline, according to the National Alliance on Mental Illness.ĭealing with fatigue and tiredness from sertraline can be a frustrating experience, but it usually passes.Īs the medication reaches a steady state in your body, you’ll generally start to notice a less pronounced effect on your energy levels before this side effect fades completely. If you’re using sertraline to treat depression, fatigue and tiredness from the medication can also be compounded by the effects of depression on your mood. Fatigue and Tirednessįatigue and drowsiness are two of the most common side effects of sertraline (Zoloft), as well as several other SSRIs. We’ve listed these common side effects below. Like other SSRIs, it can cause a range of mild side effects that typically occur during the first few weeks of treatment. Sertraline belongs to a class of medications known as selective serotonin reuptake inhibitors, or SSRIs.

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